Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines
Authors
Abstract:
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
similar resources
Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.
full textRegioselective synthesis of novel N2- and N4-substituted 7-methylpyrazolo[4,5-e][1,2,4]thiadiazines.
The new compound 7-methylpyrazolo[4,5-e][1,2,4]thiadiazin-3(2H,4H)-one1,1-dioxide (5) was synthesized and its novel mono N2- or N4-substituted derivatives 6 and 7 were prepared by regioselective N-alkylation of 5 with different molar ratios of NaH and alkyl halides. Based on the regioselective alkylation conditions found a facile one-pot synthesis of N2,N4-disubstituted pyrazolo[4,5-e][1,2,4] t...
full textnovel synthesis of pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors
treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-n,n, 1,5-tetramethyl-1h-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. the latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.
full textSynthesis of novel 1,2,4-triazoles and triazolo-thiadiazines as anticancer agents
A new series of 7-arylazo-5H -3-(trifluoromethyl)-6-methyl-1,2,4-triazolo-[3,4-b ]-1,3,4-thiadiazines was prepared by reaction of 4-amino-3-trifluoromethyl-5-mercapto-1,2,4-triazoles with N -aryl-2-oxo-propane hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine. Furthermore, Schiff bases of 4-amino-5-mercapto-1,2,4triazole derivatives were reacted with a variety of hyd...
full textsynthesis of vitamin e novel analogues as anti-cancer compounds
background antioxidant compounds have been shown to slow down the development of chemically induced tumors. it has been estimated that most of human cancer cases are due to environmental factors and would be preventable if the main risks could be identified. the potential of vitamin e as a cancer preventive agent has been studied and individuals whose intake of vitamin e was above average showe...
full textMy Resources
Journal title
volume 1 issue 1
pages 16- 20
publication date 2011-05-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023